Sodium Hydroxide → 5-[4-(benzyloxy)phenyl]-2H-tetrazole

HRID 423254

反応式

HRID 423254 の反応式
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N-:17]=[N+:18]=[N-:19].[Na+].[Cl-].[NH4+].[OH-].[Na+]>CN(C)C=O>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]2[N:17]=[N:18][NH:19][N:14]=2)=[CH:15][CH:16]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 14798Sodium HydroxideHCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 5613714-Benzyloxybenzonitrile

生成物 1

HCID 47709095-[4-(benzyloxy)phenyl]-2H-tetrazole収率 95%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
110 °C

実験手順

To a solution of 4-benzyloxybenzonitrile (2.0 g) in dimethylformamide (15 mL) were added sodium azide (932 mg) and ammonium chloride (767 mg). The mixture was stirred at 110° C. overnight under heating and then allowed to stand for cooling to room temperature. 1N aqueous sodium hydroxide was added thereto to adjust the pH to about 10, followed by washing with diethyl ether. To the aqueous layer was added 1N hydrochloric acid, and the resulting precipitated solid was filtered to give the title compound (2.29 g).

後処理

  1. temperatureunder heating
  2. temperaturefor cooling to room temperature
  3. washby washing with diethyl ether
  4. additionTo the aqueous layer was added 1N hydrochloric acid
  5. customthe resulting precipitated solid
  6. filtrationwas filtered

出典と根拠

ORDレコード
ord-aa7d65929a8b4b7f87d2782eda47a500
出典データセット
uspto-grants-2012_01
特許番号
US08101774B2

関連ノート

読み込み中…