Hydrochloric Acid → HCID 178517814、化合物

反応式

[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1.[OH-:20].[Na+].Cl>C1COCC1>[Cl:1][C:2]1[N:3]=[C:4]([OH:20])[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1

参加物

実験手順

To a suspension of 2,4-dichloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine (1.3 g) in THF was added 1N NaOH (6.6 ml). The reaction mixture was stirred at room temperature for 30 min. Then another 2.2 ml 1N NaOH was added. After 2 hours, the reaction mixture was neutralized by adding 2N HCl and extracted with EtOAc. The organic layer was dried and concentrated until solid was formed. The solid was collected by filtration, washed with acetonitrile to give 0.97 g 2-chloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidin-4-ol.