Tetrahydrofuran → [4-Bromo-2-(methanesulfonyl)phenyl]methanol
反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:3]=1.C1COCC1.[BH4-].[Na+]>CCO>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[C:4]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:3]=1参加物
5
実験手順
To a solution of 4-bromo-2-methansulfonyl-benzaldehyde (1.0 g, 3.88 mmol) in EtOH (11 mL)/THF (2.5 mL) was added NaBH4 (1.29 g, 34.2 mmol) in three portions. The reaction was carefully quenched with water and the product was extracted with EtOAc, dried (Na2SO4), and purified by silica gel chromatography to give 735 mg of (4-bromo-2-methansulfonyl-phenyl)-methanol.
後処理
- customThe reaction was carefully quenched with water
- extractionthe product was extracted with EtOAc
- dry with materialdried (Na2SO4)
- custompurified by silica gel chromatography
出典と根拠
- ORDレコード
- ord-3d88b6e748454650a9020d7c708611a7
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08536187B2
反応ノート
読み込み中…