反応式
[OH:1][CH2:2][CH2:3][S:4][CH3:5].[H-].[Na+].F[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N+:15]([O-:17])=[O:16]>O1CCCC1>[CH3:5][S:4][CH2:3][CH2:2][O:1][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N+:15]([O-:17])=[O:16]参加物
5
反応条件
- 温度
- 40 °C
実験手順
16.3 g of 2-hydroxyethylmethyl sulfide are added dropwise at 20°-25° C. to 8.5 g of a 55% NaH suspension in 150 ml of absolute tetrahydrofuran. The mixture is stirred for 1 hour at 20° C. and for 20 minutes at 40° C., and 25 g of 1-fluoro-2-nitrobenzene are subsequently added at 20° C. After the suspension has been stirred for 10 hours at 20° C., the tetrahydrofuran is distilled off in vacuo. Water is added to the residue, and extraction is repeatedly performed with ether. There is thus obtained an oil which can be used without further purification for the following hydrogenation stage.
後処理
- stirringAfter the suspension has been stirred for 10 hours at 20° C.
- distillationthe tetrahydrofuran is distilled off in vacuo
- additionWater is added to the residue, and extraction
- customThere is thus obtained an oil which
- customcan be used without further purification for the following hydrogenation stage
出典と根拠
- ORDレコード
- ord-4db7c84e1eb24c088f78a0ceb966e2c1
- 出典データセット
- uspto-grants-1988_02
- 特許番号
- US04725302
関連ノート
読み込み中…