Pyridine → HCID 66703605、化合物

HRID 425985

反応式

HRID 425985 の反応式
[F:1][C:2]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].N1C=CC=CC=1.[NH2:21][C:22]1[CH:31]=[C:30]2[C:25]([CH2:26][CH2:27][C:28](=[O:33])[N:29]2[CH3:32])=[CH:24][CH:23]=1>O>[F:1][C:2]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:3]=1[C:4]([NH:21][C:22]1[CH:31]=[C:30]2[C:25]([CH2:26][CH2:27][C:28](=[O:33])[N:29]2[CH3:32])=[CH:24][CH:23]=1)=[O:5]

参加物

5

反応物 3

HCID 1049PyridineHCID 1455802-Fluoro-4-(trifluoromethyl)benzoyl chlorideHCID 33699394HCID 33699394、化合物

生成物 1

HCID 66703605HCID 66703605、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2-Fluoro-4-(trifluoromethyl)benzoyl chloride was added to a pyridine solution of 7-amino-1-methyl-3,4-dihydroquinolin-2(1H)-one, followed by stirring at room temperature for 12 hours. Water was added to the reaction liquid, followed by stirring for 30 minutes and then the precipitated crystals were collected by filtration to obtain 2-fluoro-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-4-(trifluoromethyl)benzamide.

後処理

  1. stirringby stirring for 30 minutes
  2. filtrationthe precipitated crystals were collected by filtration

出典と根拠

ORDレコード
ord-37e90418f05547b9ae14e3e6437759f8
出典データセット
uspto-grants-2012_01
特許番号
US08106190B2

関連ノート

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