Benzyl chloroformate → 2-Amino-2-methyl-1-propyl acetate hydrochloride

HRID 426847ノート

反応式

HRID 426847 の反応式
C([Cl:11])([O:3][CH2:4][C:5]1C=CC=CC=1)=O.[NH2:12][C:13]([CH3:17])([CH3:16])[CH2:14][OH:15]>ClCCl>[ClH:11].[C:4]([O:15][CH2:14][C:13]([NH2:12])([CH3:17])[CH3:16])(=[O:3])[CH3:5]

参加物

4

反応物 2

HCID 10387Benzyl chloroformateHCID 118072-Amino-2-methyl-1-propanol

生成物 1

HCID 123255442-Amino-2-methyl-1-propyl acetate hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a dichloromethane solution containing 17.1 g (0.1 mol) carbobenzoxychloride at 0° was added dropwise with stirring 18.4 g (0.2 mol) 2-amino-2-methyl-1-propanol. The reaction mixture was stirred at room temperature overnight and the 2-amino-2-methyl-1-propanol hydrochloride which formed was removed by filtration. Removal of the dichloromethane under reduced pressure afforded a colorless, viscous liquid. Distillation gave 14.9 g (0.07 mol), 70%, 2-carbobenzoxyamino-2-methyl-1-propanol, bp 144°-148° (0.3 mm); ir (neat) 3400, 3020, 2980, 1710, 1510, 1455, 1270, 1070, 730 and 680 cm-1 ; pmr (CDCl3) δ 7.2 (s, 5H), 5.4 (bs, 1H), 4.9 (s, 2H), 4.2 (bs, 1H), 3.4 (s, 2H) and 1.2 (s, 6H) ppm.

後処理

  1. additionwas added dropwise

出典と根拠

ORDレコード
ord-a66d9aef3a004b6fa275e39d0c2a9e8f
出典データセット
uspto-grants-1979_10
特許番号
US04171452

反応ノート

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