Anthranilic Acid → 3,5-Dichlorobenzoic acid

HRID 426929

反応式

HRID 426929 の反応式
N[C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[ClH:11].[Cl:12]Cl.N(OC(C)C)=O>O.C(O)C>[Cl:11][C:10]1[CH:2]=[C:3]([CH:7]=[C:8]([Cl:12])[CH:9]=1)[C:4]([OH:6])=[O:5]

参加物

7

反応物 4

HCID 227Anthranilic AcidHCID 313Hydrochloric Acid2 回HCID 10929Isopropyl nitriteHCID 24526Chlorine

生成物 1

HCID 58113,5-Dichlorobenzoic acid収率 75%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒2 回

実験手順

137 parts of 2-aminobenzoic acid are introduced into 800 parts of ethanol, 50 parts of hydrochloric acid (20% strength of weight) and 500 parts of water. 163 parts of chlorine gas are passed in over 2 hours at 80° C. 300 parts of hydrochloric acid (36 percent strength by weight) are added. 125 parts of isopropyl nitrite are introduced in the course of 7 hours at 80° C. The mixture is cooled, 800 parts of water are added and the product is filtered off. 143 parts of 3,5-dichlorobenzoic acid (75% of theory) of melting point 173°-178° C. are obtained.

後処理

  1. customare passed in over 2 hours at 80° C
  2. temperatureThe mixture is cooled
  3. filtrationthe product is filtered off

出典と根拠

ORDレコード
ord-e8f17bb12cf2427c8b7cde866133ee86
出典データセット
uspto-grants-1979_10
特許番号
US04172098

関連ノート

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