Dimethyl Sulfoxide → 2-(4-Methoxyphenyl)oxirane

HRID 427052

反応式

HRID 427052 の反応式
[H-].[Na+].CS(C)=O.[I-].[CH3:8][S+](C)C.[CH3:12][O:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]=[O:19])=[CH:16][CH:15]=1>O.O1CCCC1>[CH3:12][O:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]2[O:19][CH2:8]2)=[CH:16][CH:15]=1

参加物

7

反応物 4

HCID 679Dimethyl SulfoxideHCID 24758Sodium hydrideHCID 312444-MethoxybenzaldehydeHCID 75127Trimethylsulfonium iodide

生成物 1

HCID 980482-(4-Methoxyphenyl)oxirane

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
-5 °C

実験手順

A suspension of 4.84 g. of sodium hydride (57% mineral oil dispersion) in 70 ml. of dry dimethyl sulfoxide is heated at about 65° C. under argon with stirring for one hour. Dry tetrahydrofuran (75 ml.) is added and the resulting solution is cooled to -5° C. Trimethylsulfonium iodide (19 g., 92.8 mmole) is added very slowly and stirring is continued for about five minutes. A solution of 12.6 g. (92.8 mmole) of p-methoxybenzaldehyde in 120 ml. of tetrahydrofuran is added and the temperature is maintained at -5° C. After addition is completed the mixture is allowed to warm to room temperature, poured into water and extracted with ether. The extract is washed with saturated sodium chloride solution, dried and evaporated to give p-methoxystyrene oxide.

後処理

  1. additionA suspension of 4.84 g
  2. stirringstirring
  3. waitis continued for about five minutes
  4. temperaturethe temperature is maintained at -5° C
  5. additionAfter addition
  6. temperatureto warm to room temperature
  7. extractionextracted with ether
  8. washThe extract is washed with saturated sodium chloride solution
  9. customdried
  10. customevaporated

出典と根拠

ORDレコード
ord-d3bdaa41b7544322b405a4f2122900b8
出典データセット
uspto-grants-1979_10
特許番号
US04172890

関連ノート

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