Water → Ethyl 4-(piperidin-1-yl)benzoate
反応式
F[C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][CH:3]=1.[NH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1.O>C(#N)C>[N:13]1([C:2]2[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][CH:3]=2)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1参加物
5
実験手順
Reaction of ethyl 4-fluorobenzoate with piperidine (3 equivalents) in acetonitrile was carried out at reflux for 4 days. Dilution of the cooled reaction mixture with several volumes of water provided a precipitate, which was filtered to provide ethyl 4-(piperidin-1-yl)benzoate. Reduction of the ester with lithium aluminum hydride (2 equivalents) in tetrahydrofuran gave the corresponding alcohol (Examples 71, 72).
後処理
- temperatureat reflux for 4 days
- customprovided a precipitate, which
- filtrationwas filtered
出典と根拠
- ORDレコード
- ord-c8b15264a4eb4c2e9a59dd9bdeae15d9
- 出典データセット
- uspto-grants-2001_11
- 特許番号
- US06313100B1
反応ノート
読み込み中…