Benzaldehyde → 1-(4-Cinnamoylphenyl)-4-(4-pyridyl)piperazine

HRID 427455

反応式

HRID 427455 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=3)[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[CH:22](=O)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>[OH-].[Na+].C(O)C>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:11][CH2:12][N:13]([C:16]3[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=3)[CH2:14][CH2:15]2)=[CH:8][CH:9]=1)(=[O:3])[CH:2]=[CH:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

参加物

5

反応物 2

HCID 240BenzaldehydeHCID 183571351-(4-Acetylphenyl)-4-(4-pyridyl)piperazine

生成物 1

HCID 536791701-(4-Cinnamoylphenyl)-4-(4-pyridyl)piperazine収率 50.3%

試薬・触媒・溶媒 2

HCID 14798Sodium Hydroxide触媒HCID 702Ethanol溶媒

実験手順

A solution of 1-(4-acetylphenyl)-4-(4-pyridyl)piperazine (1.0 g), benzaldehyde (177 mg) and concentrated sodium hydroxide (3 drops) in ethanol (25 ml) was stirred at ambient temperature overnight to give a solid which was filtered, washed with ethanol and dried to give 1-(4-cinnamoylphenyl)-4-(4-pyridyl)piperazine (310 mg), m.p. 208-210° C.

後処理

  1. customto give a solid which
  2. filtrationwas filtered
  3. washwashed with ethanol
  4. customdried

出典と根拠

ORDレコード
ord-0eaeb2ce37d845478c23552ddb4c4c49
出典データセット
uspto-grants-2001_11
特許番号
US06313127B1

関連ノート

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