2-Methylbenzyl alcohol → 2-Amino-3-(2-methylbenzyloxy)pyrazine

HRID 4293

反応式

HRID 4293 の反応式
[CH3:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5].[H-].[Na+].[NH2:12][C:13]1[C:18](Cl)=[N:17][CH:16]=[CH:15][N:14]=1>CN(C)C=O>[NH2:12][C:13]1[C:18]([O:5][CH2:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=2[CH3:1])=[N:17][CH:16]=[CH:15][N:14]=1

参加物

5

反応物 3

HCID 69942-Methylbenzyl alcoholHCID 24758Sodium hydrideHCID 2762242-Amino-3-chloropyrazine

生成物 1

HCID 138259752-Amino-3-(2-methylbenzyloxy)pyrazine収率 41.5%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
65 °C

実験手順

To a solution of 2-methylbenzyl alcohol (0.985 g) in N,N-dimethylformamide (10 ml) was added 62.8% sodium hydride (0.308 g) under a nitrogen atmosphere and then stirred for 30 minutes. 2-Amino-3-chloropyrazine (0.87 g) was added to the solution and the mixture was heated at 65° C. for 2 hours and poured onto crushed ice. The resulting precipitates were collected by filtration, washed with n-hexane, and dried in a desiccator to give 2-amino-3-(2-methylbenzyloxy)pyrazine (0.6 g).

後処理

  1. additionpoured
  2. customonto crushed ice
  3. customThe resulting precipitates
  4. filtrationwere collected by filtration
  5. washwashed with n-hexane
  6. customdried in a desiccator

出典と根拠

ORDレコード
ord-163ac3e349334314939c73ed51b57929
出典データセット
uspto-grants-1988_02
特許番号
US04725601

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