Styrene → trans-Stilbene

HRID 429608

反応式

HRID 429608 の反応式
C([O-])(=O)C.[Na+].Cl[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[CH2:13]=[CH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>[P+](C1C=CC=CC=1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[Cl-].CN(C=O)C>[C:7]1(/[CH:13]=[CH:14]/[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[C:7]1(/[CH:13]=[CH:14]\[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[C:7]1([C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH2:13])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

参加物

8

反応物 3

HCID 7501StyreneHCID 7964ChlorobenzeneHCID 517045Sodium Acetate

生成物 3

HCID 107401,1-Diphenylethylene収率 14.4%HCID 638088trans-Stilbene収率 84.9%HCID 5356785cis-Stilbene収率 0.7%

試薬・触媒・溶媒 2

HCID 164911Tetraphenylphosphonium Chloride触媒HCID 6228Dimethylformamide溶媒

実験手順

A reaction is performed as described in Example 1, except that 10.3 mg (0.04 mmol) of (CH3CN)2PdCl2, 59.7 mg (0.16 mmol) of Ph4PCl, 157.6 mg (1.92 mmol) of anhydrous sodium acetate, 107.1 mg (0.95 mmol) of chlorobenzene and 136.2 mg (1.31 mmol) of styrene in 1 ml of DMF are reacted. Stirring is performed at 150° C. for 8 hours. With 95.6% conversion of Cl-benzene, a 70.4% yield of Heck products (84.9% trans-stilbene, 0.7% cis-stilbene, and 14.4% 1,1-diphenylethene) is obtained.

後処理

  1. customare reacted

出典と根拠

ORDレコード
ord-a2489af76f8f455489a19371317c7868
出典データセット
uspto-grants-2001_11
特許番号
US06316675B1

関連ノート

読み込み中…