Pyridine → 1-(2,3-Dihydrobenzofuran-5-yl)propan-2-one
反応式
[CH3:1][C:2](=C)[CH2:3][C:4]1[CH:5]=[CH:6][C:7]2[O:11][CH2:10][CH2:9][C:8]=2[CH:12]=1.N1C=CC=CC=1.[O:20]=[O+][O-].NC(N)=S>C(Cl)Cl.CO>[O:11]1[C:7]2[CH:6]=[CH:5][C:4]([CH2:3][C:2](=[O:20])[CH3:1])=[CH:12][C:8]=2[CH2:9][CH2:10]1参加物
7
実験手順
A solution of 5-(2-methylallyl)-2,3-dihydrobenzofuran (58 grams, 0.333 mole) and pyridine (27 ml) in methylene chloride (450 ml) and methanol (150 ml) was cooled in a dry ice/acetone bath and a stream of ozone passed through for 1.0 hour. Thiourea (18 grams, 0.24 mole) was added and the mixture was warmed to room temperature. The resultant precipitate was filtered and the mother liquor evaporated to give an oil which was distilled under reduced pressure to give 1-(2,3-dihydrobenzofuran-5-yl)propan-2-one (32 grams, 54%), bp. 110° C. @ 120 mT.
後処理
- custompassed through for 1.0 hour
- filtrationThe resultant precipitate was filtered
- customthe mother liquor evaporated
- customto give an oil which
- distillationwas distilled under reduced pressure
出典と根拠
- ORDレコード
- ord-bd0ba028d81047af97497267bc46110a
- 出典データセット
- uspto-grants-2001_11
- 特許番号
- US06319920B1
反応ノート
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