p-Toluenesulfonic acid → 1-Pyrrolidino-1-cyclohexene

HRID 430633

反応式

HRID 430633 の反応式
[C:1]1(C)[CH:6]=[CH:5][C:4](S(O)(=O)=O)=[CH:3][CH:2]=1.C1(=O)CCCCC1.[NH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1>C1C=CC=CC=1>[C:1]1([N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH:6]=1

参加物

5

反応物 3

HCID 6101p-Toluenesulfonic acidHCID 7967CyclohexanoneHCID 31268Pyrrolidine

生成物 1

HCID 707681-Pyrrolidino-1-cyclohexene

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

1 g of para-toluenesulphonic acid is added to a mixture of 20 mmol of cyclohexanone and 22 mmol of pyrrolidine in 200 ml of dry benzene. The reaction mixture is stirred at reflux until, in the infra-red, the ketone has disappeared, with the enamine concomitantly appearing. The solvent is then evaporated off and the crude residue is purified by distillation in vacuo.

後処理

  1. customThe solvent is then evaporated off
  2. distillationthe crude residue is purified by distillation in vacuo

出典と根拠

ORDレコード
ord-cdac14b14a784ab9adc38381ddf9d823
出典データセット
uspto-grants-2001_11
特許番号
US06323220B1

関連ノート

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