6-Aminonicotinic acid → (6-Aminopyridin-3-yl)(4-methylpiperazin-1-yl)methanone

HRID 43064

反応式

HRID 43064 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH3:11][N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>>[NH2:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:15]2[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH2:14]2)=[O:8])=[CH:9][CH:10]=1

参加物

3

反応物 2

HCID 184966-Aminonicotinic acidHCID 531671-Methylpiperazine

生成物 1

HCID 57781845(6-Aminopyridin-3-yl)(4-methylpiperazin-1-yl)methanone

反応条件

温度
0 °C

実験手順

The title compound was prepared in analogy to the procedure described in Step 14.1 but using 6-amino-nicotinic acid and 1-methylpiperazine. The reaction mixture was stirred overnight at 0° C. DCM was used for dilution and extraction instead of EtOAc. The dried organic phase was concentrated to afford an impure sample of the title compound which was used without further purification.

後処理

  1. customThe title compound was prepared in analogy to the procedure
  2. extractionDCM was used for dilution and extraction instead of EtOAc
  3. concentrationThe dried organic phase was concentrated

出典と根拠

ORDレコード
ord-65aef1e3c6b14e0c923194c276e06732
出典データセット
uspto-grants-2013_09
特許番号
US08536175B2

関連ノート

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