Hydrochloric Acid → HCID 12857528、化合物

HRID 430899ノート

反応式

HRID 430899 の反応式
[OH-].[Na+].[CH3:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][OH:10].[CH2:11]([O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH3:22])[CH:12]1[O:14][CH2:13]1.Cl>>[CH3:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][O:10][CH2:13][CH:12]([OH:14])[CH2:11][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH3:22]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 8134Diethylene Glycol Monomethyl EtherHCID 14798Sodium HydroxideHCID 104422242-(2-methoxyethoxy)ethyl glycidyl ether

生成物 1

HCID 12857528HCID 12857528、化合物収率 75%

反応条件

温度
70 °C

実験手順

44.0 g (1.1 mol) of NaOH pellets were added to 360 g (3.0 mol) of diethyleneglycol monomethyl ether, and 176 g (1.0 mol) of 2-(2-methoxyethoxy)ethyl glycidyl ether was gradually dropwise added while stirring at 70° C. After the completion of dropwise addition, the mixture was stirred for about one hour and then stood for cooling at room temperature. Then, the mixture was neutralized with hydrochloric acid, a precipitated salt was filtered off and the liquid was condensed. The liquid was purified by vacuum distillation to give 222 g of 1,3-bis[2-(2-methoxyethoxy)ethoxy]-2-propanol (yield: 75%). The distillation temperature was from 171 to 175° C./0.8 mmHg.

後処理

  1. additionwas gradually dropwise added
  2. additionAfter the completion of dropwise addition
  3. stirringthe mixture was stirred for about one hour
  4. temperaturefor cooling at room temperature
  5. filtrationa precipitated salt was filtered off
  6. customcondensed
  7. distillationThe liquid was purified by vacuum distillation

出典と根拠

ORDレコード
ord-1408dede6baa48f59d66e4cb6804a746
出典データセット
uspto-grants-2003_12
特許番号
US06656252B2

反応ノート

読み込み中…