Hydrogen Bromide → 3-Bromopiperidine-2,6-dione

HRID 430954

反応式

HRID 430954 の反応式
[Br:1]Br.[C:3]1(=[O:10])[NH:8][C:7](=[O:9])[CH2:6][CH2:5][CH2:4]1.Br>C(Cl)(Cl)Cl>[Br:1][CH:4]1[CH2:5][CH2:6][C:7](=[O:9])[NH:8][C:3]1=[O:10]

参加物

5

反応物 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 70726Glutarimide

生成物 1

HCID 125707753-Bromopiperidine-2,6-dione

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

反応条件

温度
110 °C

実験手順

4.5 ml bromine were added to 10.2 g glutarimide suspended in 20 ml chloroform and the mixture was stirred in a closed vessel for 90 minutes at a bath temperature of 110° C. After cooling, the vessel was opened and stirring was continued until no more hydrogen bromide escaped. The reaction mixture was evaporated in vacuo, the residue dissolved in ethanol and evaporated again. 17.1 g (99% of theoretical) of the title compound remained in the form of practically white crystals, which melted at 76 to 83° C.

後処理

  1. temperatureAfter cooling
  2. stirringstirring
  3. customThe reaction mixture was evaporated in vacuo
  4. dissolutionthe residue dissolved in ethanol
  5. customevaporated again

出典と根拠

ORDレコード
ord-e08265c7b9ea453a829702908d998a35
出典データセット
uspto-grants-2003_12
特許番号
US06656937B2

関連ノート

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