Acetyl chloride → N-Butyl-N-[5-(2-chloro-6-fluorophenyl)-imidazo[1,2-b][1,2,4]triazol-6-yl]-acetamide

HRID 431234

反応式

HRID 431234 の反応式
[NH2:1][C:2]1[N:6]=[CH:5][NH:4][N:3]=1.[CH2:7]([N+:11]#[C-:12])[CH2:8][CH2:9][CH3:10].[Cl:13][C:14]1[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[C:15]=1[CH:16]=O.[C:23](Cl)(=[O:25])[CH3:24]>Cl(O)(=O)(=O)=O>[CH2:7]([N:11]([C:12]1[N:3]2[NH:4][CH:5]=[N:6][C:2]2=[N:1][C:16]=1[C:15]1[C:18]([F:22])=[CH:19][CH:20]=[CH:21][C:14]=1[Cl:13])[C:23](=[O:25])[CH3:24])[CH2:8][CH2:9][CH3:10]

参加物

6

反応物 4

HCID 6367Acetyl chlorideHCID 678472-Chloro-6-fluorobenzaldehydeHCID 76008Butyl isocyanideHCID 178418311HCID 178418311、化合物

生成物 1

HCID 22335588N-Butyl-N-[5-(2-chloro-6-fluorophenyl)-imidazo[1,2-b][1,2,4]triazol-6-yl]-acetamide

試薬・触媒・溶媒 1

HCID 24247Perchloric Acid溶媒

実験手順

Compound 55 was prepared in accordance with the general synthesis instructions from 1.0 ml (0.1 mmol) 3-amino-1,2,4-triazole solution (0.1 M, MC), 0.575 ml (0.115 mmol) n-butylisonitrile solution (0.2 M, MC), 0.500 ml (0.15 mmol) 2-chloro-6-fluorobenzaldehyde solution (0.3 M, MC) and 10 μl perchloric acid (w=20%) and by reaction with acetyl chloride, the excess acetyl chloride being removed in vacuo.

後処理

  1. customthe excess acetyl chloride being removed in vacuo

出典と根拠

ORDレコード
ord-0878b30f5d244b1aa6b435ecbb45aa6c
出典データセット
uspto-grants-2003_12
特許番号
US06657064B2

関連ノート

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