2,2-Dimethyl-3-phenylpropanoic acid → 2,2-Dimethyl-3-phenylpropanoyl chloride

HRID 432398

反応式

HRID 432398 の反応式
[CH3:1][C:2]([CH3:13])([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3](O)=[O:4].C(Cl)(=O)C([Cl:17])=O>C(Cl)(Cl)Cl.CN(C)C=O>[CH3:1][C:2]([CH3:13])([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3]([Cl:17])=[O:4]

参加物

5

反応物 2

HCID 218802,2-Dimethyl-3-phenylpropanoic acidHCID 65578Oxalyl chloride

生成物 1

HCID 133072292,2-Dimethyl-3-phenylpropanoyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6212Chloroform溶媒

反応条件

温度
0 °C

実験手順

A solution of 2,2-dimethyl-3-phenylpropanoic acid (0.856 g, 4.8 mmol) in chloroform (6 mL) at 0° C. was treated with oxalyl chloride (3.05 g, 24 mmol) and 1 drop of dimethylformamide. The reaction solution was stirred for 1 h at 0° C. The ice bath was removed and the reaction mixture stirred at room temperature over night. The solvent was removed under reduced pressure and dried under high vacuum to afford a quantitative amount of 2,2-dimethyl-3-phenylpropanoyl chloride. The oil was directly used in the following reaction.

後処理

  1. customThe ice bath was removed
  2. stirringthe reaction mixture stirred at room temperature over night
  3. customThe solvent was removed under reduced pressure
  4. customdried under high vacuum

出典と根拠

ORDレコード
ord-adbedfaa1bb149a6a18b2c46b931bf2b
出典データセット
uspto-grants-2003_12
特許番号
US06660744B1

関連ノート

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