Sodium Hydroxide → (S)-1-benzoyl-3-piperidinecarboxylic acid

HRID 432821

反応式

HRID 432821 の反応式
S1C=CC=C1CC(N1CCCC(C(O)=O)C1)=O.[C:18]([N:26]1[CH2:31][CH2:30][CH2:29][C@H:28]([C:32]([O:34]CC)=[O:33])[CH2:27]1)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[OH-].[Na+]>C(O)C>[C:18]([N:26]1[CH2:31][CH2:30][CH2:29][C@H:28]([C:32]([OH:34])=[O:33])[CH2:27]1)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 670251(S)-ethyl 1-benzoyl-3-piperidinecarboxylateHCID 167909951-(2-(Thiophen-2-yl)acetyl)piperidine-3-carboxylic acid

生成物 1

HCID 743141(S)-1-benzoyl-3-piperidinecarboxylic acid収率 92.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The reaction was run in the same manner as 1-(2-thiopeneacetyl)-3-piperidine carboxylic acid, starting with (S)-ethyl 1-benzoyl-3-piperidinecarboxylate (8.71 g; 33.31 mmol), 1N sodium hydroxide (100 ml) and absolute ethanol (100 ml), giving (S)-1-benzoyl-3-piperidinecarboxylic acid as a white solid (7.20 g). MS m/z (negative ion) 232 ([M-H]−; 100).

出典と根拠

ORDレコード
ord-e75c0336ea6648c4ad4215840a5bc935
出典データセット
uspto-grants-2003_12
特許番号
US06664271B1

関連ノート

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