Chloroform → 1-tert-Butyl-3-ethyl-3,5,5-trimethylpiperazin-2-one

反応式

[CH3:1][C:2]([NH2:10])([CH3:9])[CH2:3][NH:4][C:5]([CH3:8])([CH3:7])[CH3:6].[CH3:11][C:12]([CH2:14][CH3:15])=O.[OH-:16].[Na+].[CH:18](Cl)(Cl)Cl>>[C:5]([N:4]1[CH2:3][C:2]([CH3:9])([CH3:1])[NH:10][C:12]([CH2:14][CH3:15])([CH3:18])[C:11]1=[O:16])([CH3:8])([CH3:7])[CH3:6]

参加物

反応物 4

HCID 6212Chloroform

HCID 6569Methyl Ethyl Ketone

HCID 14798Sodium Hydroxide

HCID 125809891,2-Propanediamine, N1-(1,1-dimethylethyl)-2-methyl-

生成物 1

HCID 187604851-tert-Butyl-3-ethyl-3,5,5-trimethylpiperazin-2-one収率 99%

実験手順

In analogy to Example B21, 1,1-dimethyl-2-t-butylaminoethylamin, methylethylketon, chloroform and NaOH are reacted to give the raw title compound (99%) as an yellow oil.

出典と根拠

ORDレコード: ord-27d773ee409f497591cdd9b8d06e8646
出典データセット: uspto-grants-2003_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06664353B2

反応ノート

読み込み中…