2-Nitropropane → 4-Methyl-4-nitrovaleronitrile

HRID 432983ノート

反応式

HRID 432983 の反応式
[C:1](#[N:4])[CH:2]=[CH2:3].[N+:5]([CH:8]([CH3:10])[CH3:9])([O-:7])=[O:6].[OH-].[Na+]>[Cl-].C([N+](C)(C)C)CCCCCCCCCCCCCCC>[CH3:9][C:8]([N+:5]([O-:7])=[O:6])([CH3:10])[CH2:3][CH2:2][C:1]#[N:4]

参加物

5

反応物 3

HCID 3982-NitropropaneHCID 7855AcrylonitrileHCID 14798Sodium Hydroxide

生成物 1

HCID 38791404-Methyl-4-nitrovaleronitrile

試薬・触媒・溶媒 1

HCID 8154Hexadecyltrimethylammonium chloride触媒

実験手順

(vii-1) Acrylonitrile and 2-nitropropane are reacted in the presence of hexadecyltrimethyl ammonium chloride in an aqueous alkali solvent such as aqueous sodium hydroxide solution and the like. Then, the reaction mixture is extracted to give 4-methyl-4-nitrovaleronitrile (European Journal of organic Chemistry (1998), (2), 355-357). The obtained 4-methyl-4-nitrovaleronitrile can be isolated and/or purified by a conventional method, such as crystallization, chromatography and the like, but generally, can be used in the next step without isolation and/or purification.

後処理

  1. extractionThen, the reaction mixture is extracted

出典と根拠

ORDレコード
ord-756f7ca001c64a679544616e96739e67
出典データセット
uspto-grants-2003_12
特許番号
US06664412B2

反応ノート

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