Phenylacetone → 1-Phenyl-2-propanol

HRID 434370

反応式

HRID 434370 の反応式
[BH4-].[Na+].[C:3]1([CH2:9][C:10](=[O:12])[CH3:11])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>CO>[C:3]1([CH2:9][CH:10]([OH:12])[CH3:11])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 7678PhenylacetoneHCID 4311764Sodium borohydride

生成物 1

HCID 941851-Phenyl-2-propanol収率 86.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Sodium borohydride (10.0 g) was added portionwise to an ice cold stirred solution of 1-phenylpropan-2-one (30.0 g) in methanol (500 ml). The mixture was stirred for 4 hours, evaporated and partitioned between water (100 ml) and chloroform (200 ml). The organic phase was dried (MgSO4) and evaporated to give the product as a colourless oil (26.4 g).

後処理

  1. customevaporated
  2. custompartitioned between water (100 ml) and chloroform (200 ml)
  3. dry with materialThe organic phase was dried (MgSO4)
  4. customevaporated

出典と根拠

ORDレコード
ord-e0ce0ce0e0664f128aefe1478c6790fe
出典データセット
uspto-grants-1983_08
特許番号
US04396627

関連ノート

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