Dabco → 2-[(dimethylamino)sulfonylmethyl]-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]benzenesulfonamide

HRID 434462ノート

反応式

HRID 434462 の反応式
[CH3:1][N:2]([CH3:19])[S:3]([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13]([N:16]=[C:17]=[O:18])(=[O:15])=[O:14])(=[O:5])=[O:4].[NH2:20][C:21]1[N:26]=[C:25]([O:27][CH3:28])[CH:24]=[C:23]([O:29][CH3:30])[N:22]=1.C1N2CCN(CC2)C1>C(#N)C>[CH3:1][N:2]([CH3:19])[S:3]([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13]([NH:16][C:17]([NH:20][C:21]1[N:22]=[C:23]([O:29][CH3:30])[CH:24]=[C:25]([O:27][CH3:28])[N:26]=1)=[O:18])(=[O:14])=[O:15])(=[O:4])=[O:5]

参加物

5

反応物 3

HCID 9237DabcoHCID 1189462-Amino-4,6-dimethoxypyrimidineHCID 131787292-[(Dimethylsulfamoyl)methyl]benzene-1-sulfonyl isocyanate

生成物 1

HCID 204925842-[(dimethylamino)sulfonylmethyl]-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]benzenesulfonamide収率 78.8%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 2.6 g of the product of Example 5, 0.9 g of 2-amino-4,6-dimethoxypyrimidine and a few crystals of DABCO in 15 ml of dry acetonitrile was heated at 50°-55° for 1 hour under a nitrogen atmosphere, then stirred overnight at room temperature. The precipitate was filtered off, washed with acetonitrile and dried to give 2.1 g of 2-[(dimethylamino)sulfonylmethyl]-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]benzenesulfonamide, m.p. 172°-176°.

後処理

  1. filtrationThe precipitate was filtered off
  2. washwashed with acetonitrile
  3. customdried

出典と根拠

ORDレコード
ord-8dec5d50d7f140b5a4959d613fded792
出典データセット
uspto-grants-1983_08
特許番号
US04397679

反応ノート

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