Butyl iodide → 1-(5-Acetyl-3-butyl-2,4-dihydroxyphenyl)ethanone

HRID 435203

反応式

HRID 435203 の反応式
[C:1]([C:4]1[CH:10]=[C:9]([C:11](=[O:13])[CH3:12])[C:7]([OH:8])=[CH:6][C:5]=1[OH:14])(=[O:3])[CH3:2].[OH-].[Na+].I[CH2:18][CH2:19][CH2:20][CH3:21]>O>[CH2:18]([C:6]1[C:7]([OH:8])=[C:9]([C:11](=[O:13])[CH3:12])[CH:10]=[C:4]([C:1](=[O:3])[CH3:2])[C:5]=1[OH:14])[CH2:19][CH2:20][CH3:21]

参加物

5

反応物 3

HCID 10962Butyl iodideHCID 14798Sodium HydroxideHCID 750974,6-Diacetylresorcinol

生成物 1

HCID 27751671-(5-Acetyl-3-butyl-2,4-dihydroxyphenyl)ethanone

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

4,6-Diacetyl resorcinol (485 g, 2.5 m) sodium hydroxide (220 g, 5 m), 1-iodobutane (285 ml, 2.5 m) and water (2 l) were heated on a steam bath for 16 hours, cooled to 20° and the yellow-white precipitate filtered and washed with water. The solid was washed with dilute hydrochloric acid, extracted into chloroform (2×1.5 l) and the chloroform solution washed with water (2 l) and brine (1 l), then dried (anhyd. Na2SO4). Filtration and removal of solvent gave an oil (420 g) which crystallised on standing.

後処理

  1. temperaturecooled to 20°
  2. filtrationthe yellow-white precipitate filtered
  3. washwashed with water
  4. washThe solid was washed with dilute hydrochloric acid
  5. extractionextracted into chloroform (2×1.5 l)
  6. washthe chloroform solution washed with water (2 l) and brine (1 l)
  7. dry with materialdried (anhyd. Na2SO4)
  8. filtrationFiltration and removal of solvent

出典と根拠

ORDレコード
ord-e8faf5cc04d049b79b4b4ea636fbb0b6
出典データセット
uspto-grants-1983_08
特許番号
US04400542

関連ノート

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