4-Nitrophenyl trifluoroacetate → HCID 178524481、化合物

HRID 436362

反応式

HRID 436362 の反応式
[NH:1]1[CH:8]=[C:7]([C:9]([OH:11])=[O:10])[C:5](=[O:6])[NH:4][C:2]1=[O:3].FC(F)(F)C(O[C:17]1[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=1)=O>N1C=CC=CC=1>[OH:3][C:2]1[N:4]=[C:5]([OH:6])[C:7]([C:9]([O:11][C:17]2[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=2)=[O:10])=[CH:8][N:1]=1

参加物

4

反応物 2

HCID 695694-Nitrophenyl trifluoroacetateHCID 903011,2,3,4-Tetrahydro-2,4-dioxo-5-pyrimidinecarboxylic acid

生成物 1

HCID 178524481HCID 178524481、化合物収率 65.3%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
45 °C

実験手順

Uracil-5-carboxylic acid (1.0 g) is dissolved in dry pyridine (20 ml) under heating. p-Nitrophenyl trifluroacetate (1.8 g) is added to the solution which is subsequently stirred at 45° C for 30 minutes. Then, the solution is concentrated to dryness under reduced pressure, and the cyrstals thus obtained are washed with chloroform and then acetone to give the active ester, i.e. p-nitrophenyl 2,4-dihydroxypyrimidine-5-carboxylate (1.16 g). M.P. 298°-299° C (decomp.).

後処理

  1. temperatureunder heating
  2. concentrationThen, the solution is concentrated to dryness under reduced pressure
  3. customthe cyrstals thus obtained
  4. washare washed with chloroform

出典と根拠

ORDレコード
ord-973d09fdd4f848038325b3f993b5ec89
出典データセット
uspto-grants-1977_02
特許番号
US04008220

関連ノート

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