Hydrochloric Acid → 2-Phenyl-3-(3-pyrrolidinopropionyl)benzofuran

HRID 436497ノート

反応式

HRID 436497 の反応式
[C:1]1([C:7]2[O:8][C:9]3[CH:18]=[CH:17][CH:16]=[CH:15][C:10]=3[C:11]=2[C:12](=[O:14])[CH3:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:19]=O.[NH:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1.Cl>C(O)(C)C.C(O)C>[C:1]1([C:7]2[O:8][C:9]3[CH:18]=[CH:17][CH:16]=[CH:15][C:10]=3[C:11]=2[C:12](=[O:14])[CH2:13][CH2:19][N:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 31268PyrrolidineHCID 130247261-(2-Phenylbenzofuran-3-yl)ethanone

生成物 1

HCID 214527512-Phenyl-3-(3-pyrrolidinopropionyl)benzofuran

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 3776Isopropanol溶媒

実験手順

To a solution of 23.6 grams of 2-phenyl-3-acetylbenzofuran in 70 milliliters of isopropanol was added 4.2 grams of paraformaldehyde, 10 grams of pyrrolidine and 30 milliliters of a saturated solution of hydrogen chloride in ethanol and the mixture was heated under reflux at its boiling point for 10 hours.

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux at its boiling point for 10 hours

出典と根拠

ORDレコード
ord-fceb410546054e4badc44089db582370
出典データセット
uspto-grants-1977_02
特許番号
US04009184

反応ノート

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