Diethyl Sulfate → N-[4-(diethylamino)-2-methylphenyl]acetamide

HRID 436551

反応式

HRID 436551 の反応式
[NH:1]([C:5]1[CH:13]=[CH:12][C:8]([NH:9][CH2:10][CH3:11])=[CH:7][C:6]=1[CH3:14])[C:2]([CH3:4])=[O:3].S(OCC)(O[CH2:19][CH3:20])(=O)=O.[OH-].[Na+]>O>[NH:1]([C:5]1[CH:13]=[CH:12][C:8]([N:9]([CH2:19][CH3:20])[CH2:10][CH3:11])=[CH:7][C:6]=1[CH3:14])[C:2]([CH3:4])=[O:3]

参加物

5

反応物 3

HCID 6163Diethyl SulfateHCID 14798Sodium HydroxideHCID 214528314-Acetamino-3-methyl-N-ethylaniline

生成物 1

HCID 222177N-[4-(diethylamino)-2-methylphenyl]acetamide収率 64.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

19.1g (0.1 mole) of 4-acetamino-3-methyl-N-ethylaniline obtained in Example 1, Part C, and 100g of water were mixed, and, after 12.5g of diethyl sulfate were added dropwise thereto while stirring, the entire reaction system was stirred overnight at room temperature. Next, the reaction mixture was neutralized with sodium hydroxide and the crystals separated were recrystallized from methanol to obtain 11.5g of white crystals of 4-acetamino-3-methyl-(N,N-diethyl)aniline.

後処理

  1. stirringthe entire reaction system was stirred overnight at room temperature
  2. customthe crystals separated
  3. customwere recrystallized from methanol

出典と根拠

ORDレコード
ord-07f5cee7c9e849128dbff41ea39d7b24
出典データセット
uspto-grants-1977_02
特許番号
US04009205

関連ノート

読み込み中…