Sodium Iodide → HCID 14810575、化合物

HRID 437384

反応式

HRID 437384 の反応式
Cl[CH2:2][CH2:3][CH2:4][C:5]([O:7][CH3:8])=[O:6].[CH3:9][C@H:10]1[CH2:15][CH2:14][CH2:13][C@@H:12]([CH3:16])[NH:11]1.[I-].[Na+]>C1(C)C(C)=CC=CC=1>[CH3:9][C@H:10]1[CH2:15][CH2:14][CH2:13][C@@H:12]([CH3:16])[N:11]1[CH2:2][CH2:3][CH2:4][C:5]([O:7][CH3:8])=[O:6]

参加物

5

反応物 3

HCID 5238Sodium IodideHCID 76612Butanoic acid, 4-chloro-, methyl esterHCID 641768rel-(2R,6S)-2,6-Dimethylpiperidine

生成物 1

HCID 14810575HCID 14810575、化合物

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

A mixture of 273 g. of methyl 4-chlorobutyrate, 460 g. of cis-2,6-dimethylpiperidine, 10 g. of sodium iodide and 300 ml. of xylene is stirred and heated at reflux for 44 hours, then cooled and filtered. The filter cake is washed with xylene and the combined filtrate and washings are evaporated at reduced pressure to give cis-2,6-dimethyl-1-piperidinebutyric acid, methyl ester which is purified by distillation; b.p. 79°-81° C./0.5 mm.

後処理

  1. additionA mixture of 273 g
  2. temperatureheated
  3. temperatureat reflux for 44 hours
  4. temperaturecooled
  5. filtrationfiltered
  6. washThe filter cake is washed with xylene
  7. customthe combined filtrate and washings are evaporated at reduced pressure

出典と根拠

ORDレコード
ord-d2f3b55717314692bbbb371b3e3261ff
出典データセット
uspto-grants-1977_06
特許番号
US04031101

関連ノート

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