Sodium Iodide → cis-2,6-Dimethyl-1-piperidinebutyric acid, methyl ester
反応式
Cl[CH2:2][CH2:3][CH2:4][C:5]([O:7][CH3:8])=[O:6].[CH3:9][C@H:10]1[CH2:15][CH2:14][CH2:13][C@@H:12]([CH3:16])[NH:11]1.[I-].[Na+]>C1(C)C(C)=CC=CC=1>[CH3:9][C@H:10]1[CH2:15][CH2:14][CH2:13][C@@H:12]([CH3:16])[N:11]1[CH2:2][CH2:3][CH2:4][C:5]([O:7][CH3:8])=[O:6]参加物
5
実験手順
A mixture of 273 g. of methyl 4-chlorobutyrate, 460 g. of cis-2,6-dimethylpiperidine, 10 g. of sodium iodide and 300 ml. of xylene is stirred and heated at reflux for 44 hours, then cooled and filtered. The filter cake is washed with xylene and the combined filtrate and washings are evaporated at reduced pressure to give cis-2,6-dimethyl-1-piperidinebutyric acid, methyl ester which is purified by distillation; b.p. 79°-81° C./0.5 mm.
後処理
- additionA mixture of 273 g
- temperatureheated
- temperatureat reflux for 44 hours
- temperaturecooled
- filtrationfiltered
- washThe filter cake is washed with xylene
- customthe combined filtrate and washings are evaporated at reduced pressure
出典と根拠
- ORDレコード
- ord-d2f3b55717314692bbbb371b3e3261ff
- 出典データセット
- uspto-grants-1977_06
- 特許番号
- US04031101
反応ノート
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