Bicarbonate Ion → Fluoromidine

HRID 437399

反応式

HRID 437399 の反応式
CS(O[N:6]1[C:14]2[C:9](=[N:10][CH:11]=[C:12]([Cl:15])[CH:13]=2)[N:8]=[C:7]1[C:16]([F:19])([F:18])[F:17])(=O)=O.[I-].[Na+].CCOCC.C(=O)(O)[O-]>CC(C)=O>[Cl:15][C:12]1[CH:13]=[C:14]2[NH:6][C:7]([C:16]([F:17])([F:18])[F:19])=[N:8][C:9]2=[N:10][CH:11]=1

参加物

6

反応物 4

HCID 769Bicarbonate IonHCID 3283Diethyl EtherHCID 5238Sodium IodideHCID 203599241-(METHYLSULFONYLOXY)-6-CHLORO-2-(TRIFLUOROMETHYL)-1H-IMIDAZO(4,5-b)PYRIDINE

生成物 1

HCID 911208Fluoromidine収率 73%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒2 回

実験手順

1-(Methylsulfonyloxy)-6-chloro-2-(trifluoromethyl)-1H-imidazo [4,5-b] pyridine (20 milligrams) in 0.5 milliliter of acetone was treated with 0.1 gram of sodium iodide in 0.5 milliliter of acetone. The reaction mixture was shaken with ether and bicarbonate solution. The ether portion was dried over magnesium sulfate and evaporated, yielding 10 milligrams (about 73 percent) of 6-chloro-2-(trifluoromethyl)-1H-imidazo [4,5-b] pyridine.

後処理

  1. dry with materialThe ether portion was dried over magnesium sulfate
  2. customevaporated

出典と根拠

ORDレコード
ord-fde4c1ece5ef45c68a2011d043d95a1d
出典データセット
uspto-grants-1977_06
特許番号
US04031107

関連ノート

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