1,3-Cyclohexanedione → HCID 178418531、化合物

HRID 4374

反応式

HRID 4374 の反応式
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH2:10])=[CH:5][CH:4]=1.[OH-].[Na+].[C:13]1(=O)[CH2:18][CH2:17][CH2:16][C:15](=[O:19])[CH2:14]1>O>[F:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][N:10]=[C:13]2[CH2:18][CH2:17][CH2:16][C:15]([OH:19])=[CH:14]2)=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 104341,3-CyclohexanedioneHCID 14798Sodium HydroxideHCID 699814-Fluorophenylhydrazine hydrochloride

生成物 1

HCID 178418531HCID 178418531、化合物収率 96.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒3 回

実験手順

A suspension of 4-fluorophenylhydrazine hydrochloride (50 g) in water (500 ml) was treated with sodium hydroxide (12.3 g) in water (50 ml) and the resultant solution added to solution of cyclohexane-1,3-dione (97%, 35.6 g) in water (300 ml) over 2 h under nitrogen with stirring. After a further 30 min, the precipitate was filtered off, washed with water (50 ml), air dried for 1 h, and dried in vacuo over phosphorus pentoxide at 75° to give the title compound as a powder (65.3 g) m.p. 175°-176°.

後処理

  1. filtrationthe precipitate was filtered off
  2. washwashed with water (50 ml), air
  3. customdried for 1 h
  4. dry with materialdried in vacuo over phosphorus pentoxide at 75°

出典と根拠

ORDレコード
ord-3b691c0f3b274492971e450bdceebda6
出典データセット
uspto-grants-1988_02
特許番号
US04725615

関連ノート

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