Pinacolone → Methyl pivaloylacetate

HRID 437480

反応式

HRID 437480 の反応式
[H-].[Na+].[CH3:3][C:4](=[O:9])[C:5]([CH3:8])([CH3:7])[CH3:6].[C:10](=O)([O:13]C)[O:11][CH3:12]>CN(C)P(=O)(N(C)C)N(C)C>[CH3:12][O:11][C:10](=[O:13])[CH2:3][C:4](=[O:9])[C:5]([CH3:8])([CH3:7])[CH3:6]

参加物

5

反応物 3

HCID 6416PinacoloneHCID 12021Dimethyl CarbonateHCID 24758Sodium hydride

生成物 1

HCID 99597Methyl pivaloylacetate収率 83.5%

試薬・触媒・溶媒 1

HCID 12679Hexamethylphosphoramide溶媒

実験手順

60 g of sodium hydride were suspended in 450 cc of dimethyl carbonate and 100 cc of hexamethyl phosphoric acid triamide. 100 g of pinacolone (92%) were added slowly at 45° C and on completion of the addition, the reaction mixture was processed as described in 3 above. The yield was 83.5% of pivaloyl acetic acid methyl ester.

出典と根拠

ORDレコード
ord-0fb85a1d813f4f5ea5765711fed7dda6
出典データセット
uspto-grants-1977_06
特許番号
US04031130

関連ノート

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