Aziridine → HCID 21428829、化合物

HRID 437618

反応式

HRID 437618 の反応式
[NH:1]1[CH2:3][CH2:2]1.C(=O)([O-])O.[Na+].[OH:9][C:10]1[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12](Cl)=[O:13].[OH-].[Na+]>O.ClC(Cl)Cl>[OH:9][C:10]1[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12]([N:1]1[CH2:3][CH2:2]1)=[O:13]

参加物

7

反応物 4

HCID 9033AziridineHCID 14798Sodium HydroxideHCID 74041Salicyloyl chlorideHCID 516892Sodium Bicarbonate

生成物 1

HCID 21428829HCID 21428829、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6212Chloroform溶媒

反応条件

温度
-5 °C

実験手順

To 690 parts of a solution of aziridine in water 0.875M are added 42 parts of sodium hydrogen carbonate while cooling in an ice-salt bath at -5° C. While stirring vigorously, there is added dropwise, during a 30 minutes period, a solution of 78.8 parts of 2-hydroxybenzoyl chloride in 150 parts of trichloromethane at a temperature below 5° C. The reaction mixture is allowed to reach 25° C while stirring, and a diluted sodium hydroxide solution is added to pH 8. The product is extracted three times with trichloromethane. The combined extracts are washed three times with water, dried, filtered and evaporated, yielding 56 parts of 1-(2-hydroxybenzoyl)aziridine as a residue.

後処理

  1. additionthere is added dropwise, during a 30 minutes period
  2. customat a temperature below 5° C
  3. customto reach 25° C
  4. stirringwhile stirring
  5. extractionThe product is extracted three times with trichloromethane
  6. washThe combined extracts are washed three times with water
  7. customdried
  8. filtrationfiltered
  9. customevaporated

出典と根拠

ORDレコード
ord-d831ca452c1d40e9aa3a624c99eea2a9
出典データセット
uspto-grants-1977_06
特許番号
US04031226

関連ノート

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