Hydrogen Sulfide → HCID 54512368、化合物

HRID 439300ノート

反応式

HRID 439300 の反応式
[C:1]([CH:3]([NH:9][C:10]([C:12]1[S:16][C:15]([NH:17][CH2:18][CH3:19])=[N:14][C:13]=1[CH3:20])=[O:11])[C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)#[N:2].[SH2:21]>N1C=CC=CC=1>[C:1]([CH:3]([NH:9][C:10]([C:12]1[S:16][C:15]([NH:17][CH2:18][CH3:19])=[N:14][C:13]=1[CH3:20])=[O:11])[C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)(=[S:21])[NH2:2]

参加物

4

反応物 2

HCID 402Hydrogen SulfideHCID 22465462HCID 22465462、化合物

生成物 1

HCID 54512368HCID 54512368、化合物収率 91%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
60 °C

実験手順

0.85g of 2-ethylamino-4-methyl-thiazole-5-carboxylic acid (cyano-thiophen-2-yl-methyl)-amide (5) was dissolved in 2ml of pyridine and the reaction solution was stirred for 6 hours at 60° C. while introducing hydrogen sulfide gas. After removing the pyridine, the residue was recrystallized from ethylacetate to obtain 0.86g (Yield 91%) of the title compound.

後処理

  1. customAfter removing the pyridine
  2. customthe residue was recrystallized from ethylacetate

出典と根拠

ORDレコード
ord-cf354ad9ab3346b7b0f91ff67c255bb9
出典データセット
uspto-grants-1996_05
特許番号
US05514643

反応ノート

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