Ethanolamine → 2-(1,3-Benzoxazol-2-ylamino)ethanol
反応式
Cl[C:2]1[O:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[CH2:11]([CH2:13][NH2:14])[OH:12]>O1CCCC1>[O:3]1[C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=[C:2]1[NH:14][CH2:13][CH2:11][OH:12]参加物
4
実験手順
A solution of 2-chlorobenzoxazole (12.78 g) in dry tetrahydrofuran (50 ml) was added, over 10 minutes, to a stirred, ice-cooled solution of ethanolamine (15.3 g) in dry tetrahydrofuran (400 ml). The mixture was heated at reflux overnight, cooled, and the solvent evaporated. The residue was partitioned between water (500 ml) and dichloromethane (500 ml), and the resulting white solid filtered off, washed with dichloromethane and dried in vacuo to afford the title compound m.p. 162°-4° C.
後処理
- temperatureThe mixture was heated
- temperatureat reflux overnight
- temperaturecooled
- customthe solvent evaporated
- customThe residue was partitioned between water (500 ml) and dichloromethane (500 ml)
- filtrationthe resulting white solid filtered off
- washwashed with dichloromethane
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-efbc21db57d24d84affd0a2ac0a712d2
- 出典データセット
- uspto-grants-1996_05
- 特許番号
- US05521201
反応ノート
読み込み中…