Water → 4-[2-Hydroxy-2-(5-methyl-phenyl-4-oxazolyl)ethoxy]benzonitrile

HRID 4412

反応式

HRID 4412 の反応式
[BH4-].[Na+].C[C:4]1[O:8][C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:6][C:5]=1[C:15](=[O:26])[CH2:16][O:17][C:18]1[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=1.[CH3:27]N(C)C=O.O>CO>[OH:26][CH:15]([C:5]1[N:6]=[C:7]([C:9]2[CH:14]=[C:13]([CH3:27])[CH:12]=[CH:11][CH:10]=2)[O:8][CH:4]=1)[CH2:16][O:17][C:18]1[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=1

参加物

6

反応物 4

HCID 962WaterHCID 6228DimethylformamideHCID 4311764Sodium borohydrideHCID 137139794-[2-(5-Methyl-2-phenyl-4-oxazolyl)-2-oxoethoxy]benzonitrile

生成物 1

HCID 542872044-[2-Hydroxy-2-(5-methyl-phenyl-4-oxazolyl)ethoxy]benzonitrile収率 92.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Sodium borohydride (0.654 mg) was added to a suspension of 4-[2-(5-methyl-2-phenyl-4-oxazolyl)-2-oxoethoxy]benzonitrile (5.5 g) in methanol (100 ml)-N,N-dimethylformamide (50 ml), followed by stirring at room temperature for 1 hour. The reaction solution was poured into water and the crystals which separated out were collected by filtration to give 4-[2-hydroxy-2-(5-methyl-phenyl-4-oxazolyl)ethoxy]benzonitrile (5.1 g, 92.7%). Recrystallization from acetone afforded colorless neddles, m.p. 176°-177° C.

後処理

  1. customthe crystals which separated out
  2. filtrationwere collected by filtration

出典と根拠

ORDレコード
ord-2f9a930e708d48b38d38a3a790caddee
出典データセット
uspto-grants-1988_02
特許番号
US04725610

関連ノート

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