Benzyl Alcohol → 2-Amino-3-morpholino-5-benzyloxypyrazine

HRID 441754ノート

反応式

HRID 441754 の反応式
[H-].[Na+].[CH2:3]([OH:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[NH2:11][C:12]1[C:17]([N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)=[N:16][C:15](Br)=[CH:14][N:13]=1>C1C=CC=CC=1>[NH2:11][C:12]1[C:17]([N:18]2[CH2:19][CH2:20][O:21][CH2:22][CH2:23]2)=[N:16][C:15]([O:10][CH2:3][C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)=[CH:14][N:13]=1

参加物

5

反応物 3

HCID 244Benzyl AlcoholHCID 24758Sodium hydrideHCID 167404415-Bromo-3-morpholinopyrazin-2-amine

生成物 1

HCID 205289342-Amino-3-morpholino-5-benzyloxypyrazine

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

実験手順

Sodium hydride (0.1 mole) is added to benzyl alcohol (0.1 mole) in 100 ml. dry benzene and the mixture is refluxed one to two hours. The cooled solution is treated with 0.1 mole of 2-amino-3-morpholino-5-bromopyrazine in 100 ml. of benzene and the resulting mixture refluxed for 20-60 hours whereupon it is cooled, washed with water, dried and evaporated to give 2-amino-3-morpholino-5-benzyloxypyrazine.

後処理

  1. temperatureis cooled
  2. washwashed with water
  3. customdried
  4. customevaporated

出典と根拠

ORDレコード
ord-a57c79a316fc4fe19a1677b8b9505dc3
出典データセット
uspto-grants-1977_08
特許番号
US04042586

反応ノート

読み込み中…