Benzyl Bromide → 2-Benzyl-6-methoxyisoquinolinium bromide
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[N:8][CH:7]=[CH:6]2.[CH2:13]([Br:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CC(C)=O.CCOCC>[Br-:20].[CH2:13]([N+:8]1[CH:7]=[CH:6][C:5]2[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[CH:4]=2)[CH:9]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1参加物
5
実験手順
6-Methoxyisoquinoline (1.6 g) and benzyl bromide (2 ml) in acetone (75 ml) were heated under reflux for 1 hour. The mixture was diluted with ether and cooled to 0°. The solid was filtered off and recrystallised from methanol/ether, and had m.p. 155°-158°.
後処理
- temperatureunder reflux for 1 hour
- temperaturecooled to 0°
- filtrationThe solid was filtered off
- customrecrystallised from methanol/ether
出典と根拠
- ORDレコード
- ord-a515023c47354e99bfa7c2376c17c423
- 出典データセット
- uspto-grants-1977_08
- 特許番号
- US04042697
反応ノート
読み込み中…