Trichloroacetyl chloride → 2-(Trichloroacetyl)pyrrole

HRID 44255

反応式

HRID 44255 の反応式
[Cl:1][C:2]([Cl:7])([Cl:6])[C:3](Cl)=[O:4].[NH:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1.C(=O)([O-])[O-].[K+].[K+]>C(OCC)C.O>[Cl:1][C:2]([Cl:7])([Cl:6])[C:3]([C:9]1[NH:8][CH:12]=[CH:11][CH:10]=1)=[O:4]

参加物

6

反応物 3

HCID 6420Trichloroacetyl chlorideHCID 8027PyrroleHCID 11430Potassium Carbonate

生成物 1

HCID 3214872-(Trichloroacetyl)pyrrole

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒2 回

実験手順

To a solution of trichloroacetyl chloride (160.7 mmoles) in ethyl ether (26 ml) there is added, dropwise over a period of 3 hours, a solution of pyrrole (149 mmoles) in ethyl ether (83 ml). After stirring for a further hour, a solution of potassium carbonate (94 mmoles) in water (39 ml) is added dropwise. The phases are separated and the organic phase is dried over sodium sulphate and filtered. Active carbon is added to this organic phase. After stirring for 5 minutes, the organic phase is filtered and evaporated to dryness to yield the title product.

後処理

  1. customThe phases are separated
  2. dry with materialthe organic phase is dried over sodium sulphate
  3. filtrationfiltered
  4. additionActive carbon is added to this organic phase
  5. stirringAfter stirring for 5 minutes
  6. filtrationthe organic phase is filtered
  7. customevaporated to dryness

出典と根拠

ORDレコード
ord-c606efcc6d174fd5af17b1eca1f8b113
出典データセット
uspto-grants-2013_09
特許番号
US08541412B2

関連ノート

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