Hydrochloric Acid → 4'-Methoxycarbonyloxy-4-biphenylcarboxylic acid

HRID 442578

反応式

HRID 442578 の反応式
Cl[C:2]([O:4][CH3:5])=[O:3].[OH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([OH:21])=[O:20])=[CH:15][CH:14]=2)=[CH:9][CH:8]=1.[OH-].[Na+].Cl>O>[CH3:5][O:4][C:2]([O:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([OH:21])=[O:20])=[CH:15][CH:14]=2)=[CH:11][CH:12]=1)=[O:3]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 6586Methyl chloroformateHCID 14798Sodium HydroxideHCID 3015564'-Hydroxy-4-biphenylcarboxylic acid

生成物 1

HCID 183284084'-Methoxycarbonyloxy-4-biphenylcarboxylic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Methyl chloroformate (12.90 g, 0.137 mol) was added dropwise, over 10 minutes, to a stirred, cooled (5° C.) solution of compound 3 (10.00 g, 0.047 mol) in sodium hydroxide (5.44 g, 0.136 mol) and water (150 ml). During the addition a white precipitate was formed and this stirred mixture was allowed to warm to room temperature overnight. The resultant mixture was carefully acidified (pH 5) with dilute hydrochloric acid and the resultant voluminous white solid was filtered off, washed with water until acid-free and dried (phosphorus pentoxide) in vacuo.

後処理

  1. additionDuring the addition a white precipitate
  2. customwas formed
  3. filtrationthe resultant voluminous white solid was filtered off
  4. washwashed with water until acid-free and
  5. dry with materialdried (phosphorus pentoxide) in vacuo

出典と根拠

ORDレコード
ord-c973779e5d994e7f9e28e6e1ee5328ac
出典データセット
uspto-grants-1999_04
特許番号
US05891358

関連ノート

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