Methyl iodide → [5-(Ethoxycarbonyl)-1H-pyrrol-3-yl]-N,N,N-trimethyl-methanaminium iodide
反応式
[CH3:1][N:2]([CH2:4][C:5]1[CH:6]=[C:7]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[NH:8][CH:9]=1)[CH3:3].[CH3:15][I:16]>O1CCCC1.C(Cl)Cl>[I-:16].[CH2:13]([O:12][C:10]([C:7]1[NH:8][CH:9]=[C:5]([CH2:4][N+:2]([CH3:15])([CH3:1])[CH3:3])[CH:6]=1)=[O:11])[CH3:14]参加物
5
実験手順
To a solution of the product obtained in Step D (0.3 g) in a mixture of tetrahydrofuran (2.2 ml) and CH2Cl2 (2.2 ml) there is added methyl iodide (0.350 ml). A precipitate appears. The reaction mixture is stirred for one hour at ambient temperature and is then left at 4° C. overnight. The reaction mixture is evaporated to dryness and the residue obtained is used directly in the next Step.
後処理
- waitis then left at 4° C. overnight
- customThe reaction mixture is evaporated to dryness
- customthe residue obtained
出典と根拠
- ORDレコード
- ord-7f981b74c6044b5eb7b7f067d1d18b6f
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08541412B2
反応ノート
読み込み中…