Ethanolamine → 2-[2-(4-Nitro-phenyl)-ethylamino]-ethanol
反応式
Br[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][CH:5]=1.[NH2:13][CH2:14][CH2:15][OH:16]>>[N+:10]([C:7]1[CH:8]=[CH:9][C:4]([CH2:3][CH2:2][NH:13][CH2:14][CH2:15][OH:16])=[CH:5][CH:6]=1)([O-:12])=[O:11]参加物
3
反応条件
- 温度
- 150 °C
実験手順
A mixture of 1-(2-bromo-ethyl)-4-nitro-benzene (86.9 mmoles) and 2-amino-ethanol (869 mmoles) is heated at 150° C. under microwave activation for 10 minutes. The reaction mixture is evaporated to dryness and the residue obtained is purified on silica gel (SiO2; gradient DCM/MeOH) to yield the title product, which is used directly in the next Step.
後処理
- customThe reaction mixture is evaporated to dryness
- customthe residue obtained
- customis purified on silica gel (SiO2; gradient DCM/MeOH)
出典と根拠
- ORDレコード
- ord-2b4fbf189855456f819977f42058ce7e
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08541412B2
反応ノート
読み込み中…