Ethanolamine → 2-[2-(4-Nitro-phenyl)-ethylamino]-ethanol

HRID 44293

反応式

HRID 44293 の反応式
Br[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][CH:5]=1.[NH2:13][CH2:14][CH2:15][OH:16]>>[N+:10]([C:7]1[CH:8]=[CH:9][C:4]([CH2:3][CH2:2][NH:13][CH2:14][CH2:15][OH:16])=[CH:5][CH:6]=1)([O-:12])=[O:11]

参加物

3

反応物 2

HCID 700EthanolamineHCID 792664-Nitrophenethyl bromide

生成物 1

HCID 227227442-[2-(4-Nitro-phenyl)-ethylamino]-ethanol

反応条件

温度
150 °C

実験手順

A mixture of 1-(2-bromo-ethyl)-4-nitro-benzene (86.9 mmoles) and 2-amino-ethanol (869 mmoles) is heated at 150° C. under microwave activation for 10 minutes. The reaction mixture is evaporated to dryness and the residue obtained is purified on silica gel (SiO2; gradient DCM/MeOH) to yield the title product, which is used directly in the next Step.

後処理

  1. customThe reaction mixture is evaporated to dryness
  2. customthe residue obtained
  3. customis purified on silica gel (SiO2; gradient DCM/MeOH)

出典と根拠

ORDレコード
ord-2b4fbf189855456f819977f42058ce7e
出典データセット
uspto-grants-2013_09
特許番号
US08541412B2

関連ノート

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