Water → Ethyl furfuryloxycarbonyl-glycinate

HRID 4433

反応式

HRID 4433 の反応式
[C:1](=[O:13])([O:6][CH2:7][C:8]1[O:12][CH:11]=[CH:10][CH:9]=1)OC(Cl)C.[NH2:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17].O.[Na+].[Cl-]>C1COCC1.C(=O)([O-])[O-].[K+].[K+]>[CH2:7]([O:6][C:1]([NH:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[O:13])[C:8]1[O:12][CH:11]=[CH:10][CH:9]=1

参加物

7

反応物 4

HCID 962WaterHCID 5234Sodium ChlorideHCID 12176Glycine ethyl esterHCID 13506124alpha-Chloroethyl furfuryl carbonate

生成物 1

HCID 13506132Ethyl furfuryloxycarbonyl-glycinate収率 66%

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 11430Potassium Carbonate溶媒

実験手順

2.05 g (10 mmol) of α-chloroethyl furfuryl carbonate are added to a solution of 1.03 g (10 mmol) of ethyl glycinate in 6 ml of THF and 4 ml of 0.5M potassium carbonate solution maintained at between 5° and 10° C. The mixture is allowed to come to room temperature and is stirred for 18 hours. 50 ml of water saturated with NaCl are added and the mixture is extracted with 3×40 ml of ethyl ether. The organic phases are combined and dried over magnesium sulphate. After removal of the solvent and distillation, 1.5 g (66% yield) of the expected product is collected.

後処理

  1. temperaturemaintained at between 5° and 10° C
  2. customto come to room temperature
  3. extractionthe mixture is extracted with 3×40 ml of ethyl ether
  4. dry with materialdried over magnesium sulphate

出典と根拠

ORDレコード
ord-9b0ce90354764aed88d683b8b0a391d1
出典データセット
uspto-grants-1988_02
特許番号
US04725680

関連ノート

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