Potassium Iodide → 2-(Ethylamino)-4,5-dimethylthiophene-3-carbonitrile

HRID 44357

反応式

HRID 44357 の反応式
[CH2:1]([NH:8][C:9]1[S:10][C:11]([CH3:17])=[C:12]([CH3:16])[C:13]=1[C:14]#[N:15])[C:2]1C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+].C(I)C>C(#N)C.C(OCC)(=O)C>[CH2:1]([NH:8][C:9]1[S:10][C:11]([CH3:17])=[C:12]([CH3:16])[C:13]=1[C:14]#[N:15])[CH3:2]

参加物

7

反応物 4

HCID 4875Potassium IodideHCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 3194512-(Benzylamino)-4,5-dimethylthiophene-3-carbonitrile

生成物 1

HCID 574569162-(Ethylamino)-4,5-dimethylthiophene-3-carbonitrile

試薬・触媒・溶媒 2

HCID 6342Acetonitrile溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a mixture of 2-(benzylamino)-4,5-dimethylthiophene-3-carbonitrile (302 mg, 2.0 mmol), potassium carbonate (276 mg, 2.0 mmol), and a catalytic amount of potassium iodide in acetonitrile (1 mL) in a 20 mL microwave vial was added ethyl iodide (310 mg, 2.0 mmol). The reaction vial was placed in a microwave reactor for 15 minutes at 165° C. The reaction mixture was dissolved in ethyl acetate and washed with water and brine. The ethyl acetate portion was dried over sodium sulfate and solvent was evaporated under reduced pressure, and the product was purified by prep HPLC using acetonitrile/water as solvent. MS 181 (MH+).

後処理

  1. customThe reaction
  2. washwashed with water and brine
  3. dry with materialThe ethyl acetate portion was dried over sodium sulfate and solvent
  4. customwas evaporated under reduced pressure
  5. customthe product was purified by prep HPLC

出典と根拠

ORDレコード
ord-21dd526d8f404127827d9310b7134341
出典データセット
uspto-grants-2013_09
特許番号
US08541421B2

関連ノート

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