Sodium Hydroxide → 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepin-3-carboxylic acid
反応式
[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][C:11]([C:13]([O:15]C)=[O:14])=[CH:12][C:7]=2[S:6][C:5]2[CH:17]=[CH:18][CH:19]=[CH:20][C:4]=2[NH:3]1.[OH-].[Na+]>O1CCCC1>[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][C:11]([C:13]([OH:15])=[O:14])=[CH:12][C:7]=2[S:6][C:5]2[CH:17]=[CH:18][CH:19]=[CH:20][C:4]=2[NH:3]1参加物
4
実験手順
Dissolve 1.49 gm of the ester of Example 2 in 50 cc of tetrahydrofuran. Add 40 cc of 10% sodium hydroxide and stir at room temperature for 3 hours. Evaporate the tetrahydrofuran and extract the aqueous residue with ethyl acetate. Acidify and separate the precipitate by filtration. Wash the precipitate well with water and dry in vacuo to obtain the title product (m.p. 362°-364° C.).
後処理
- customEvaporate the tetrahydrofuran
- extractionextract the aqueous residue with ethyl acetate
- customseparate the precipitate
- filtrationby filtration
- washWash the precipitate well with water
- customdry in vacuo
出典と根拠
- ORDレコード
- ord-6a01973b78f14887b3cdac652343957a
- 出典データセット
- uspto-grants-1981_04
- 特許番号
- US04263207
反応ノート
読み込み中…