Dimethylamine → 2-Carboxy-4-methyl-2-[(dimethylamino)methyl]pentanoic acid

HRID 444192

反応式

HRID 444192 の反応式
[C:1]([CH:4]([CH2:8][CH:9]([CH3:11])[CH3:10])[C:5]([OH:7])=[O:6])([OH:3])=[O:2].[CH3:12][NH:13][CH3:14].[CH2:15]=O>O>[C:5]([C:4]([CH2:12][N:13]([CH3:15])[CH3:14])([CH2:8][CH:9]([CH3:11])[CH3:10])[C:1]([OH:3])=[O:2])([OH:7])=[O:6]

参加物

5

反応物 3

HCID 674DimethylamineHCID 712FormaldehydeHCID 78069Isobutylmalonic acid

生成物 1

HCID 130175562-Carboxy-4-methyl-2-[(dimethylamino)methyl]pentanoic acid収率 63%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
5 °C

実験手順

2-Carboxy-4-methylpentanoic acid (67 g) is suspended in 400 ml of water and cooled to 5° C. Aqueous 40% dimethylamine (50 g) is added to the suspension followed by aqueous 37% formaldehyde (35.7 g). The resulting solution is stirred for about 16 hours and solid product is filtered and dried in vacuo to yield 57.3 g of the title compound, melting point 134°-137° C. with carbon dioxide and dimethylamine given off.

後処理

  1. filtrationsolid product is filtered
  2. customdried in vacuo

出典と根拠

ORDレコード
ord-1764e36943b84ecdaed90320f5ae4ed7
出典データセット
uspto-grants-1981_04
特許番号
US04263293

関連ノート

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