Cysteamine Hydrochloride → 2-(2-Aminoethylthiomethyl)-3-ethoxypyridine

HRID 444485ノート

反応式

HRID 444485 の反応式
Cl.[NH2:2][CH2:3][CH2:4][SH:5].[Na].Cl.Cl[CH2:9][C:10]1[C:15]([O:16][CH2:17][CH3:18])=[CH:14][CH:13]=[CH:12][N:11]=1>C(O)C>[NH2:2][CH2:3][CH2:4][S:5][CH2:9][C:10]1[C:15]([O:16][CH2:17][CH3:18])=[CH:14][CH:13]=[CH:12][N:11]=1

参加物

5

反応物 3

HCID 9082Cysteamine HydrochlorideHCID 5360545SodiumHCID 204741852-Chloromethyl-3-ethoxypyridine hydrochloride

生成物 1

HCID 204022362-(2-Aminoethylthiomethyl)-3-ethoxypyridine収率 89.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

Cysteamine hydrochloride (2.76 g) was added to a stirred mixture of sodium (1.576 g) in ethanol (75 cc) at 12°, 2-Chloromethyl-3-ethoxypyridine hydrochloride (4.60 g) in ethanol (70 cc) was added over 30 minutes to this mixture stirred at 10°-12°. The mixture was left to stand overnight, filtered and the filtrate was evaporated to dryness. The residue was dissolved in water, acidified to pH4 with hydrochloric acid and extracted with chloroform (discarded). The aqueous phase was adjusted to pH 12 with aqueous sodium hydroxide and was extracted with chloroform. The chloroform extracts were evaporated to give 2-(2-aminoethylthiomethyl)-3-ethoxypyridine (4.2 g) as an oil.

後処理

  1. waitThe mixture was left
  2. filtrationfiltered
  3. customthe filtrate was evaporated to dryness
  4. dissolutionThe residue was dissolved in water
  5. extractionextracted with chloroform (discarded)
  6. extractionwas extracted with chloroform
  7. customThe chloroform extracts were evaporated

出典と根拠

ORDレコード
ord-fa838e6c62b449d59f9eb776ffd634fd
出典データセット
uspto-grants-1981_04
特許番号
US04264608

反応ノート

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