Sodium Hydroxide → HCID 178525591、化合物

HRID 444553ノート

反応式

HRID 444553 の反応式
C([O:8][C:9]([CH2:11][CH2:12][N:13]1[C:17]([SH:18])=[N:16][N:15]=[N:14]1)=[O:10])C1C=CC=CC=1.[OH-].[Na+]>O1CCCC1>[C:9]([CH2:11][CH2:12][N:13]1[C:17]([SH:18])=[N:16][N:15]=[N:14]1)([OH:10])=[O:8]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 178520826HCID 178520826、化合物

生成物 1

HCID 178525591HCID 178525591、化合物収率 75.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 3.84 g of 1-(2-benzyloxycarbonylethyl)-1H-tetrazole-5-thiol, 30 ml of tetrahydrofuran and 29 ml of 1 N-sodium hydroxide was allowed to stand at room temperature for 2 hours. The reaction mixture was washed with ethyl acetate and the water layer was adjusted to pH 1 with 10% hydrochloric acid and extracted with ethyl acetate. The extract was washed with an aqueous solution of sodium chloride, dried and concentrated to dryness. By the above procedure there were obtained 1.9 g of powder of the captioned compound.

後処理

  1. washThe reaction mixture was washed with ethyl acetate
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with an aqueous solution of sodium chloride
  4. customdried
  5. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-2d02a35dc9c540f8955264a48157a394
出典データセット
uspto-grants-1981_04
特許番号
US04264595

反応ノート

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