Dichloromethane → 3-Amino-6-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)picolinic acid

HRID 444913

反応式

HRID 444913 の反応式
C[O:2][C:3]([C:5]1[C:10]([NH2:11])=[CH:9][C:8]([C:12]([F:15])([F:14])[F:13])=[C:7](Br)[N:6]=1)=[O:4].C(Cl)Cl.[CH3:20][N:21]1[CH:25]=[C:24](B2OC(C)(C)C(C)(C)O2)[CH:23]=[N:22]1.C([O-])([O-])=O.[Cs+].[Cs+].[OH-].[Na+]>C1COCC1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>[NH2:11][C:10]1[C:5]([C:3]([OH:2])=[O:4])=[N:6][C:7]([C:24]2[CH:23]=[N:22][N:21]([CH3:20])[CH:25]=2)=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:9]=1

参加物

8

反応物 5

HCID 6344DichloromethaneHCID 10796Cesium carbonateHCID 14798Sodium HydroxideHCID 27739871-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 58964428Methyl 3-amino-6-bromo-5-(trifluoromethyl)picolinate2 回

生成物 1

HCID 673832773-Amino-6-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)picolinic acid

試薬・触媒・溶媒 2

HCID 178418228Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)触媒HCID 8028Tetrahydrofuran溶媒

実験手順

3-Amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester (Intermediate A4) (500 mg, 1.672 mmol), PdCl2(dppf).CH2Cl2 adduct (205 mg, 0.251 mmol), 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (383 mg, 1.839 mmol) and Cs2CO3 (6.69 ml, 6.69 mmol) in THF (12 ml) under N2, was heated using microwave radiation at 150° C. for 10 minutes. 2M NaOH (5 ml) was added and the mixture was stirred at RT overnight. The mixture was filtered through Celite® (filter material) and the organic solvent was removed. The resulting aqueous layer was washed with EtOAc and acidified to pH1. The product was extracted with DCM and concentrated in vacuo to afford the title compound;

後処理

  1. customat 150° C.
  2. customfor 10 minutes
  3. filtrationThe mixture was filtered through Celite® (filter material)
  4. customthe organic solvent was removed
  5. washThe resulting aqueous layer was washed with EtOAc
  6. extractionThe product was extracted with DCM
  7. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-f8082be76d3843d5b5ac68b5abba30ad
出典データセット
uspto-grants-2013_07
特許番号
US08476269B2

関連ノート

読み込み中…