Methyl iodide → HCID 86646596、化合物
反応式
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[CH2:12][CH2:13][N:14]([C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=1)[C:15]([N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1)=[O:16].[CH3:29][I:30]>C(#N)C>[I-:30].[O:11]=[C:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:2](=[O:1])[N:3]1[CH2:12][CH2:13][N:14]([C:22]1[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=1)[C:15]([N:17]1[CH:21]=[CH:20][N+:19]([CH3:29])=[CH:18]1)=[O:16]参加物
4
実験手順
To a 50 mL round-bottomed flask was added N-(2-(1,3-dioxoisoindolin-2-yl)ethyl)-N-(4-fluorophenyl)-1H-imidazole-1-carboxamide (110 mg, 291 μmol, from step 2), acetonitrile (2 mL), methyl iodide (72.4 μl, 1163 μmol, Aldrich). The reaction mixture was stirred at RT for 24 h. The solvent was removed in vacuo to give the product (151 mg, 99.8% yield), which was used for the next step reaction without purification.